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Premature Ejaculation

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sexual dysfunctions - information, advice and treatmentThe speed of a man's ejaculation is determined genetically according to Utrecht University neuropsychiatrist, Dr Marcel Waldinger, and pharmacological researcher, Paddy Janssen, who have scrutinized a group of Dutch men with premature ejaculation. Shame may play a part - so, if you know you have sexal shame issues, see a therapist or counsellor.

You can read the results in detail in the celebrated international scientific periodical, The Journal of Sexual Medicine, but here is an outline of their research.

Waldinger and Janssen took 89 Dutch men who suffer from premature ejaculation in its primary form that is men who have always had this problem.

Waldinger pointed out that the study applied only to men who have ejaculated prematurely right from their first sexual experience and does not include men who started with the problem later on in life.

There was also a control group of another 92 men. The experiment was conducted at home and lasted a month, during which time the female partners used a stopwatch to measure the time from penetration to ejaculation every time they had intercourse.

Having listed the men in order of 'speed', the next step was to examine their individual genetic makeup.

The results were surprising but interesting. In those men who suffer from premature ejaculation, the monoamine neurotransmitter ‘serotonin' appears to be less dynamic between the nerves in the part of the brain that controls sexual function and ejaculation.

This substance is one of the many brain chemicals linked to sexual activity and desire. Its function is to transfer signals from one neuron to another, but due to the minimal activity of serotonin in men with the primary form of premature ejaculation, this signal transfer does not take place properly.

Waldinger and Janssen say that a gene which had already been discovered, that is 5-HTTLPR, seems to be responsible for the quantity and activity of serotonin, which in turn means that this gene controls the rapidity of ejaculation. There are 3 types of this gene known as LL, SL and SS.

The study shows that the LL type causes a very quick ejaculation so that on average, men with LL ejaculate at twice the speed of men with the SS type, and also they are almost twice as fast as men with the SL type.

This is just a preliminary result. The researchers are now looking for other genes that may be involved in the ejaculation process.

Marcel Waldinger has always opined that premature ejaculation was not psychological. As early as 1998, he predicted, with the aid of experimentation, that both the speed with which men ejaculate and the primary form of premature ejaculation were determined by the individual's genetic makeup.

So far he has stood alone in his theory that contradicts the prevalent idea that premature ejaculation in its primary form is a psychological disorder. The results of this new piece of research confirm the genetic theory and may in future contribute to the treatment of premature ejaculation by means of gene therapy.

A spray on delay for PE

Sufferers from premature ejaculation will be interested in a great new pharmaceutical product which was recently unveiled at the 104th Annual Scientific Meeting of the American Urological Association.

It is called PSD502, a new topical spray, which is claimed to be a safe and effective medication for premature ejaculation.

The scientists who researched the product, Doctors Wyllie, Heath and Dinsmore, presented their data on the spray's capabilities within a presentation of their 3 phase, randomized, double-blind, placebo-controlled experiment.

This is the background to the study. One of the current treatments for premature ejaculation is the squeeze technique.

Another consists of a topical cream with desensitizing properties which muffles the sensitivity of the penile skin and therefore delays ejaculation.

This is very effective but this cream requires the use of a condom plus you need to wash it all away before intercourse and moreover it may reduce sexual pleasure.

The researchers have invented a new topical spray, which consists of an aerosol fusion of lidocaine and prilocaine, which they can prove to be effective and simple to use.

This new medication is applied five minutes before intercourse. It works by selectively desensitizing the penile skin, acting only the non-keratinized skin, which is the interior lining of the foreskin and the exterior of the glans. It works without adversely affecting the sensation of ejaculation.

Delay spray

The study worked like this. The researchers chose 300 men with premature ejaculation, diagnosed under the guidelines of the International Society of Sexual Medicine that is having an intravaginal ejaculatory latency time of a minute or less.

The participants were divided into two groups, one group used the PSD502 spray and the men in the other group were given a placebo spray.

Each man had to the spray he was given five minutes prior to sexual intercourse. Both groups were equal in having an average standard of 0.6 minutes latency time before ejaculation.

The result proved the efficacy of the PSD502 spray. The PSD502 group had an average latency time of four minutes while the placebo group improved but only up to one minute.

The spray was well tolerated by both the men and their partners, and there were very few reports of systemic events or serious adverse side effects. The PSD502 group reported 2.6% of treatment-related adverse events and the placebo group reported 1%.

The study was succinctly and accurately summed up by Dr Ira D. Sharlip of the American Urological Association. He said that premature ejaculation is one of the most prolific of all man's sexual dysfunctions. It strikes at between 20% and 30% of men of all ages and social groups.

An effective, patient-friendly treatment for this terrible problem is urgently needed. This amazing new topical spray has the potential to become one of the modern world's most effective treatments for cases of PE.  But, as of November 2016 it is still not available anywhere.....

 

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